PAX GENES

Pax genes: translation

Mouse genes that contain a DNA-binding domain similar to one in the paired genes of Drosophila. 8 Pax genes have been identified, and most of them are expressed in the nervous system during development. A number of mouse mutations have been found to map to Pax genes. For example, undulated, which causes distortions of the vertebral column and sternum results from a point mutations of Pax- 1, and is expressed in the sclerotome.